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2 edition of Epstein-Barr virus and AIDS-related primary CNS lymphoma found in the catalog.

Epstein-Barr virus and AIDS-related primary CNS lymphoma

Eithne Mary Edana MacMahon

Epstein-Barr virus and AIDS-related primary CNS lymphoma

by Eithne Mary Edana MacMahon

  • 255 Want to read
  • 26 Currently reading

Published .
Written in English

    Subjects:
  • Herpesvirus 4, Human.,
  • Lymphoma, AIDS-related.,
  • Acquired Immunodeficiency Syndrome.

  • Edition Notes

    Thesis (M.D.) - University College Dublin, National University of Ireland, 1996.

    Statementby Eithne Mary Edana MacMahon.
    ID Numbers
    Open LibraryOL17161036M

    We examined the expression of the Epstein-Barr virus (EBV)-induced proteins (LMP [latent membrane protein], EBNA-2, and CD23) and a lytic protein, viral capsid antigen (VCA), in five acquired immune deficiency syndrome (AIDS)-related primary CNS lymphomas (PCNSLs). We compared that expression with the expression of the same proteins in PCNSL from six immunocompetent patients and severe. Management of primary central nervous system lymphoma for the patient with acquired immunodeficiency syndrome. Confronting a clinical catch‐22 Value of Combined Approach With Thallium Single-Photon Emission Computed Tomography and Epstein-Barr Virus DNA Polymerase Chain Reaction in CSF for the Diagnosis of AIDS-Related Primary CNS.

    Primary central nervous system lymphoma occurs more often in patients with AIDS. Epstein-Barr virus (EBV) has been detected in these tumours, but the degree of association has not been defined because of both the highly restricted expression of EBV in malignant tissue and the lack of a technique that is reliable in formalin-fixed paraffin. It is best known as the cause of infectious mononucleosis ("mono" or "glandular fever"). It is also associated with various non-malignant, premalignant, and malignant Epstein–Barr virus-associated lymphoproliferative diseases such as Burkitt lymphoma, hemophagocytic lymphohistiocytosis, and Hodgkin's lymphoma; non-lymphoid malignancies such as gastric cancer and nasopharyngeal .

    Primary central nervous system lymphoma (PCNSL) that arises in immune-deficient patients is an aggressive B-cell neoplasm that is universally associated with the EBV. Patients with EBV+ PCNSL face a particularly poor prognosis with median survival times of 2–12 months despite aggressive management with radiation therapy. We have developed a preclinical model of EBV+ PCNSL to explore. Primary CNS lymphoma, which previously was fairly common in AIDS patients, is now seen very infrequently in HIV-infected patients because of the availability of better drugs and earlier initiation of antiretroviral therapy. The majority of patients with AIDS-related lymphoma have advanced HIV disease.


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Epstein-Barr virus and AIDS-related primary CNS lymphoma by Eithne Mary Edana MacMahon Download PDF EPUB FB2

Epstein-Barr virus–positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a “provisional” entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid by: Keywords: Plasmablastic lymphoma, Central nervous system, Human immunodeficiency virus, Epstein-barr virus Background Unlike the numerous subtypes of extra-central nervous system (CNS) lymphoma, most primary central nervous system lymphomas (PCNSLs) are a high-grade non-Hodgkin’s subtype with the features of diffuse large B cell lymphoma (DLBCL).Cited by:   The Lancet ORIGINAL ARTICLES Epstein-Barr virus in AIDS-related primary central nervous system lymphoma E.

MacMahon MRCPI a P. Charache MD a D. Glass MD b R.B. Mann MD b P.S. Becker MD b D. Hayward PhD c J. McArthur MB c R.F. Ambinder MD * d * Correspondence to Dr R. Ambinder, Johns Hopkins Oncology Centre, North Bond Street, Room B, Baltimore, Cited by: Primary central nervous system lymphoma occurs more often in patients with AIDS.

Epstein-Barr virus (EBV) has been detected in these tumours, but the degree of association has not been defined because of both the highly restricted expression of EBV in malignant tissue and the lack of a technique that is reliable in formalin-fixed paraffin-embedded by: Epstein-Barr Virus Infection and Primary Central Nervous System Lymphoma, p In Goodkin K, Shapshak P, Verma A (ed), The Spectrum of Neuro-AIDS Disorders.

ASM Press, Washington, DC. doi: /ch27Author: Alex Tselis, Robert McKendall. "The Epstein Barr virus (EBV) was the first described oncovirus (cancer causing virus), which has been associated with the development of a variety of lymphoproliferative disorders, such as Burkitt, primary CNS, NK/T-cell, plasmablastic and Hodgkin lymphoma.

Introduction. Human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL) is a rare B-cell non-Hodgkin lymphoma (NHL) that is almost always positive for Epstein–Barr virus (EBV) (MacMahon et al., ; Bashir et al., ).Though in many respects similar to PCNSL in the immunocompetent counterpart, differences with respect both to the.

Vol. Feb: Value of combined approach with thallium single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphoma; pp. –   Bossolasco S, Falk KI, Ponzoni M, et al.

Ganciclovir is associated with low or undetectable Epstein-Barr virus DNA load in cerebrospinal fluid of patients with HIV-related primary central nervous system lymphoma.

Clin Infect Dis. ;42(4):e [PMID]. Fifty-one cases of acquired immunodeficiency syndrome (AIDS)—related primary brain lymphomas (AR-PBL) were investigated for clinical characteristics; human immunodeficiency virus (HIV)—associated disorders; histopathologic features; immunophenotype; Epstein-Barr virus (EBV) infection; and, when frozen tissue was available, oncogene rearrangements.

Diamond C, Taylor TH, Im T, Miradi M, Wallace M, Anton-Culver H. Highly active antiretroviral therapy is associated with improved survival among patients with AIDS-related primary central nervous system non-Hodgkin’s lymphoma. Curr HIV Res. ; –   Cinque P, Brytting M, Vago L, et al. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system.

Lancet. ;() [PMID]. Introduction. AIDS-related primary central nervous system lymphoma (AR-PCNSL) is a rare B-cell non-Hodgkin lymphoma (NHL). Prior to the use of HAART for treatment of HIV, a large proportion of PCNSL occurred in patients with advanced AIDS [1–3].Established early in the epidemic, the primary treatment for AR-PCNSL was palliative whole brain radiotherapy (WBRT).

Epstein–Barr virus (EBV) has been implicated in the development of lymphomas in immunocompromised patients. To test this hypothesis, 26 lymphomas involving the central nervous system (CNS) (11 primary, 15 systemic) were studied for the presence of EBV.

F.S. Hussain, N.S. HussainClinical utility of thallium single photon emission computed tomography and cerebrospinal fluid Epstein-Barr virus detection using polymerase chain reaction in the diagnosis of AIDS-related primary central nervous system lymphoma.

MacMahon EM, Glass JD, Hayward SD, Mann RB, Becker PS, Charache P, et al. Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet. ;()– PubMed CrossRef Google Scholar.

Cristina Valencia-Sanchez, Kristen K. Steenerson, Katalin Kelemen, Robert Orenstein, Shimon Kusne, Marie F. Grill, Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis, Journal of NeuroVirology, /s, ().

Cinque P, Brytting M, Vago L, et al. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system.

Lancet ; Plebani A, Pinzani R, Vago L, et al. Epstein-Barr virus DNA in the cerebrospinal fluid of an HIV patient with primary cerebral lymphoma. Epstein-Barr virus (EBV)—associated polymorphic lymphoproliferative disease has recently been recognized in patients with AIDS.

The pathologic features suggest a resemblance to the EBV-related lymphoproliferative disorder known as posttransplantation lymphoproliferative disorder that may be seen in up to 10% of solid organ transplant recipients [] and that may regress when. Patients diagnosed with Primary effusion lymphoma are almost always found to be positive for the HIV virus.

Other viruses often found in patients with PEL, specifically within the cancerous lymphocytes, include both Epstein-Barr virus (EBV) and human herpes virus 8, better known as Kaposi-sarcoma associated herpes virus. Primary central nervous system lymphoma (PCNSL) still occurs mainly in patients who are immunosuppressed, but its incidence is rising dramatically among immunocompetent individ Epstein‐barr virus in acquired immune deficiency syndrome (AIDS) and non‐AIDS primary central nervous system lymphoma - Deangelis - - Cancer - Wiley Online.Epstein-Barr virus (EBV) is constantly associated with AIDS-related primary lymphomas of the central nervous system (CNS).

To assess whether EBV DNA in cerebrospinal fluid (CSF) could be used as a tumour marker, CSF samples that had been taken within days before death from 85 patients with HIV infection and neurological disorders at necropsy were examined retrospectively by nested.

Latent Epstein-Barr virus (EBV) infection is associated with a heterogeneous group of non-Hodgkin lymphoma (NHL), including Burkitt’s lymphoma, NK-T lymphomas and lymphoproliferative disease (LPD).

1, – 3 Most EBV-associated NHLs are aggressive tumors characterized by rapid growth and necrosis, and the NK and T lymphomas in particular are also associated with hemophagocytosis.